Published on in Vol 14 (2025)

Preprints (earlier versions) of this paper are available at https://preprints.jmir.org/preprint/68356, first published .
Sodium Oxybate as a Potential New Treatment for Catatonia in Patients With Depression, Bipolar Disorder, or a Psychotic Disorder: Protocol for a Randomized Controlled Trial

Sodium Oxybate as a Potential New Treatment for Catatonia in Patients With Depression, Bipolar Disorder, or a Psychotic Disorder: Protocol for a Randomized Controlled Trial

Sodium Oxybate as a Potential New Treatment for Catatonia in Patients With Depression, Bipolar Disorder, or a Psychotic Disorder: Protocol for a Randomized Controlled Trial

Lilian Bot   1, 2 , MD ;   Josine G van Mill   1, 2 , MD, PhD ;   Laetitia J C A Smarius   1, 2 , MD, PhD ;   Adriaan W Hoogendoorn   1, 3 , PhD ;   Bram W C Storosum   4 , MD ;   Christiaan H Vinkers   1, 2, 3, 5 , MD, Prof Dr ;   Gabriel E Jacobs   6, 7 , PhD ;   Gert Jan Lammers   8, 9 , MD, Prof Dr ;   Hanna M Heller   1 , MD, PhD ;   Jantine C A Colen-de Koning   10 , MSci ;   Joris J B van der Vlugt   11 , MD, PhD ;   Marloes S Oudijn   1 , MD, PhD ;   Martijn S van Noorden   6 , MD, PhD ;   Pierre M Bet   5, 7, 9, 12 , PhD ;   Rolf Fronczek   8, 9 , MD, PhD ;   Heleen S van der Heijden   1 , MD, PhD ;   Sjors M M Lange   13 , MD, PhD ;   Ysbrand D van der Werf   5, 14 , Prof Dr ;   Eric R van Exel   1, 2 , MD, Prof Dr

1 Department of Psychiatry, Amsterdam University Medical Centers, Amsterdam, The Netherlands

2 Specialized Mental Health Care, GGZ InGeest, Amsterdam, The Netherlands

3 Amsterdam Public Health (Mental Health Program), Amsterdam University Medical Centers, Amsterdam, The Netherlands

4 Specialized Mental Health Care, Arkin, Amsterdam, The Netherlands

5 Compulsivity Impulsivity and Attention, Amsterdam Neuroscience, Amsterdam, The Netherlands

6 Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands

7 Department of Psychiatry Research, Centre for Human Drug Research, Leiden, The Netherlands

8 Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands

9 Expertise Centre for Epilepsy and Sleep Medicine, Stichting Epilepsie Instellingen Nederland, Heemstede, The Netherlands

10 Department of Clinical Pharmacology and Pharmacy, Amsterdam University Medical Centers, Amsterdam, The Netherlands

11 Department of Psychiatry, Molenaar Antes - Parnassiagroep, Rotterdam, The Netherlands

12 Amsterdam Public Health (Personalized Medicine Program), Amsterdam University Medical Centers, Amsterdam, The Netherlands

13 Specialized Mental Health Care, GGZ Centraal, Hilversum, The Netherlands

14 Department of Anatomy and Neurosciences, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands

Corresponding Author:

  • Lilian Bot, MD
  • Department of Psychiatry
  • Amsterdam University Medical Centers
  • Oldenaller 1
  • Amsterdam 1081 HJ
  • The Netherlands
  • Phone: 31 0204444444
  • Email: l.bot@amsterdamumc.nl