Effects of Selective Head-and-Neck Cooling on Brain Injury-Related Biomarker Levels and Symptom Rating Following a Boxing Bout: Protocol for an Exploratory Randomized Trial

Ali Al-Husseini   ¹ , MD, MSc ;   Yelverton Tegner   ² , MD, PhD ;   Kaj Blennow   ^{3, 4} , MD, PhD ;   Henrik Zetterberg   ^{3, 4, 5, 6, 7, 8} , MD, PhD ;   Niklas Marklund   ⁹ , MD, PhD

¹ Department of Clinical Sciences Lund, Neurosurgery, Lund University, Lund, Sweden

² Department of Health, Education and Technology, Division of Health and Rehabilitation, Luleå University of Technology, Luleå, Sweden

³ Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden

⁴ Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden

⁵ Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, United Kingdom

⁶ UK Dementia Research Institute, University College London, London, United Kingdom

⁷ Hong Kong Center for Neurodegenerative Diseases, Hong Kong, China (Hong Kong)

⁸ Wisconsin Alzheimer’s Disease Research Center, University of Wisconsin School of Medicine and Public Health, University of Wisconsin–Madison, Madison, WI, United States

⁹ Department of Clinical Sciences Lund, Neurosurgery, Lund University, Skåne University Hospital, Lund, Sweden