Acute Adenosine Receptor Antagonism in Combination With Acute Intermittent Hypoxia to Promote Breathing Plasticity in Amyotrophic Lateral Sclerosis: Protocol for a Randomized, Double-Blinded, Placebo-Controlled Trial

Priscila Sales de Campos   ^{1, 2, 3} , DPT, PhD ;   May Smith-Hublou   ^{1, 2} , MA, PhD ;   Wendy L Olsen   ^{1, 2, 4, 5, 6} , MS, PhD ;   Wagner Souza Leite   ^{1, 2} , MPT ;   James P Wymer   ^{4, 7} , MD, FAAN, PhD ;   Nicholas J Napoli   ^{1, 5} , MS, PhD ;   Alicia K Vose   ^{1, 8} , PhD ;   Michael T Pulley   ⁸ , MD, PhD ;   Gordon S Mitchell   ^{1, 2, 4} , PhD ;   Barbara K Smith   ^{1, 2, 9} , MPT, PhD

¹ Breathing Research and Therapeutics Center, University of Florida, Gainesville, FL, United States

² College of Public Health and Health Professions, Department of Physical Therapy, University of Florida, Gainesville, FL, United States

³ Department of Physical Therapy, Center for Health and Sports Sciences, Universidade do Estado de Santa Catarina, Florianopolis, Brazil

⁴ McKnight Brain Institute, University of Florida, Gainesville, FL, United States

⁵ College of Engineering, Department of Electrical and Computer Engineering, University of Florida, Gainesville, FL, United States

⁶ Beaver College of Health Sciences, Department of Rehabilitation Sciences, Appalachian State University, Boone, NC, United States

⁷ College of Medicine, Department of Neurology, University of Florida, Gainesville, FL, United States

⁸ College of Medicine-Jacksonville, Department of Neurology, University of Florida, Jacksonville, FL, United States

⁹ College of Medicine, Department of Pediatrics, University of Florida, Gainesville, FL, United States