Published on in Vol 15 (2026)

Preprints (earlier versions) of this paper are available at https://preprints.jmir.org/preprint/85597, first published .
Impact of the Population Medicine Multimorbidity Intervention in Xishui County (POPMIX) on People at High Risk for Chronic Obstructive Pulmonary Disease: Protocol for the POPMIX-COPD Cluster Randomized Controlled Trial

Impact of the Population Medicine Multimorbidity Intervention in Xishui County (POPMIX) on People at High Risk for Chronic Obstructive Pulmonary Disease: Protocol for the POPMIX-COPD Cluster Randomized Controlled Trial

Impact of the Population Medicine Multimorbidity Intervention in Xishui County (POPMIX) on People at High Risk for Chronic Obstructive Pulmonary Disease: Protocol for the POPMIX-COPD Cluster Randomized Controlled Trial

Chen Wang   1, 2, 3, 4 * , MD ;   Yuhao Liu   1 * , BA ;   Ke Huang   2, 3, 4 * , MD ;   Zhoutao Zheng   1 , BMed ;   Shiyu Zhang   5 , BSc ;   Wenjin Chen   1 , BMed ;   Xingyao Tang   2, 3 , MMSc ;   Zhong Cao   6 , PhD ;   Xunliang Tong   7, 8 , MD ;   Lei Tang   9 , PhD ;   Jinghan Zhao   6 , MA ;   Liu He   1 , BMed ;   Lirui Jiao   10 , MPH ;   Yingping Wang   11 , BMed ;   Tianying Zhao   11 , BM ;   Yingchi Luo   11 , BMed ;   Qiande Lai   12 , BMed ;   Xiangqin Lyu   12 , BMed ;   Qiushi Chen   13 , PhD ;   Aditi Bunker   6 , PhD ;   Sebastian Vollmer   14 , PhD ;   Pascal Geldsetzer   15, 16 , PhD ;   Dean Jamison   17 , PhD ;   Till Bärnighausen   1, 6, 18 , MD, ScD ;   Ting Yang   2, 3, 4 , MD ;   Simiao Chen   1, 4, 6 , ScD ;   POPMIX Group   19

1 School of Population Medicine and Public Health, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China

2 Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital, Beijing, China

3 National Center for Respiratory Medicine, Beijing, China

4 State Key Laboratory of Respiratory Health and Multimorbidity, Beijing, China

5 School of Health Policy and Management, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China

6 Heidelberg Institute of Global Health, Faculty of Medicine and University Hospital, Heidelberg University, Heidelberg, Germany

7 Department of Pulmonary and Crtical Care Medicine, Beijing Hospital, Beijing, China

8 Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China

9 Guizhou Medical University, Guiyang, China

10 Department of Health Policy and Management, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States

11 Center for Disease Control and Prevention of Xishui County, Zunyi, China

12 Department of Pulmonary and Critical Care Medicine, People's Hospital of Xishui County, Zunyi, China

13 The Harold and Inge Marcus Department of Industrial and Manufacturing Engineering, Pennsylvania State University, University Park, PA, United States

14 Department of Economics and Centre for Modern Indian Studies, University of Göttingen, Göttingen, Germany

15 Division of Primary Care and Population Health, Department of Medicine, Stanford University, Stanford, CA, United States

16 Chan Zuckerberg Biohub San Francisco, San Francisco, CA, United States

17 Department of Epidemiology and Biostatistics and Institute for Global Health Sciences, University of California, San Francisco, San Francisco, CA, United States

18 Department of Global and Population Health, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, United States

19 see Acknowledgments

*these authors contributed equally

Corresponding Author:

  • Simiao Chen, ScD
  • School of Population Medicine and Public Health
  • Chinese Academy of Medical Sciences & Peking Union Medical College
  • Beijige Santiao 31
  • Dongcheng District
  • Beijing 100730
  • China
  • Phone: 49 6221565948
  • Email: simiao.chen@uni-heidelberg.de