A Novel Therapy With a One-Month Ultrashort Regimen to Halt Progression From Latent Infection to Active Tuberculosis Among Close Contacts (The TB‑YOUTH Study): Protocol for a Cluster Randomized Controlled Trial

Yixuan Yang   ^{1 *} , MD ;   Feiran Zhou   ^{1 *} , MD ;   Yanfei Ren   ^{2 *} , MD ;   Fudong Li   ^{3 *} , MPH ;   Qingluan Yang   ¹ , MD ;   Yuying He   ³ , MPH ;   Xiaoling Wei   ⁴ , MD, MPH, PhD ;   Xing Wang   ² , PhD ;   Jianfeng Luo   ⁵ , PhD ;   Feng Sun   ¹ , MD ;   Lingyun Shao   ¹ , MD ;   Jinlan Li   ^{3, 6} , PhD ;   Qiaoling Ruan   ¹ , MD ;   Wenhong Zhang   ¹ , MD, PhD

¹ Department of Infectious Diseases, Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, National Medical Center for Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China

² Clinical Research Department, Shanghai Sci-Tech Inno Center for Infectious & Immunity, Shanghai, Shanghai, China

³ Institute for Tuberculosis Control, Guizhou Center for Disease Control and Prevention, Guiyang, Guizhou, China

⁴ Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada

⁵ Department of Biostatistics, School of Public Health, Fudan University, Shanghai, Shanghai, China

⁶ See Acknowledgments

*these authors contributed equally