Standardized Single-Session Cardiopulmonary Exercise Test for Measuring Peak Oxygen Uptake, Oxygen On/Off Kinetics, and Skeletal Muscle Oxygenation in ICU Survivors—ICU Combined Assessment of Cardiorespiratory Exercise (ICU-CARE) Study: Protocol for a Cross-Sectional Observational Study

Britney Blunderfield   ^{1, 2} , BKin, MSc ;   Jefferson Santana   ^{2, 3} , BSc ;   Raju Majumdar   ⁴ , BSc ;   Isuru Herath   ⁵ , MSc ;   Marcus Blouw   ^{4, 6} , MD, MHA ;   Clare Ramsey   ^{4, 6} , MD, MSc ;   Kendiss Olafson   ⁴ , MD, MPH ;   Mayson Sousa   ⁷ , PhD ;   J Gordon Boyd   ⁸ , MD, PhD ;   Dmitry Rozenberg   ^{9, 10} , MD, PhD ;   Kristine Cowley   ¹ , PhD ;   Margaret S Herridge   ^{10, 11} , MD, MPH, MSc ;   Jane Batt   ^{9, 11} , MD, PhD ;   Mac Horsburgh   ¹² , BA, MSW ;   Todd Duhamel   ^{3, 13} , PhD ;   David Christiansen   ⁶ , MD ;   Rodrigo Villar   ^{1, 2, 3 *} , PhD ;   Asher A Mendelson   ^{1, 4, 5 *} , MD, PhD

¹ Department of Physiology and Pathophysiology, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada

² Cardiorespiratory and Physiology of Exercise Research Laboratory, Faculty of Kinesiology and Recreation Management, University of Manitoba, Winnipeg, MB, Canada

³ Faculty of Kinesiology and Recreation Management, University of Manitoba, Winnipeg, MB, Canada

⁴ Section of Critical Care, Department of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada

⁵ Program of Biomedical Engineering, Price Faculty of Engineering, University of Manitoba, Winnipeg, MB, Canada

⁶ Section of Respirology, Department of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada

⁷ Department of Respiratory Therapy, College of Rehabilitation Science, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada

⁸ Department of Critical Care Medicine, Queen's University, Kingston, ON, Canada

⁹ Division of Respirology, Department of Medicine, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada

¹⁰ University Health Network, Toronto, ON, Canada

¹¹ Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada

¹² Patient Partner and ICU Survivor, Winnipeg, MB, Canada

¹³ Institute of Cardiovascular Sciences, St. Boniface Hospital Albrechtsen Research Centre, Winnipeg, MB, Canada

*these authors contributed equally