The Safety, Tolerability, and Effects on the Systemic Inflammatory Response and Renal Function of the Human Chorionic Gonadotropin Hormone-Derivative EA-230 Following On-Pump Cardiac Surgery (The EASI Study): Protocol for a Randomized, Double-Blind, Placebo-Controlled Phase 2 Study

Roger van Groenendael   ^{1, 2, 3 *} , MD ;   Remi Beunders   ^{1, 2 *} , MD ;   Jan Hofland   ³ , MD, PhD ;   Wim J Morshuis   ⁴ , MD, PhD ;   Matthijs Kox   ^{1, 2} , MSc, PhD ;   Lucas T van Eijk   ³ , MD, PhD ;   Peter Pickkers   ^{1, 2} , MD, PhD

¹ Department of Intensive Care Medicine, Radboud University Medical Center, Nijmegen, Netherlands

² Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands

³ Department of Anesthesiology, Pain and Palliative Medicine, Radboud University Medical Center, Nijmegen, Netherlands

⁴ Department of Cardiac Surgery, Radboud University Medical Center, Nijmegen, Netherlands

*these authors contributed equally