Efficacy of Cladribine Tablets as a Treatment for People With Multiple Sclerosis: Protocol for the CLOBAS Study (Cladribine, a Multicenter, Long-term Efficacy and Biomarker Australian Study)

Vicki E Maltby   ^{1, 2, 3} , BSc, PhD ;   Rodney A Lea   ^{2, 3, 4} , BSc, PhD ;   Mastura Monif   ^{5, 6, 7} , MD, PhD ;   Marzena J Fabis-Pedrini   ⁸ , BSc, PhD ;   Katherine Buzzard   ^{5, 7} , MD, PhD ;   Tomas Kalincik   ^{7, 9} , MD, PhD ;   Allan G Kermode   ^{8, 10} , MD ;   Bruce Taylor   ¹¹ , MD ;   Suzanne Hodgkinson   ^{12, 13, 14} , MD, PhD ;   Pamela McCombe   ¹⁵ , MD, PhD ;   Helmut Butzkueven   ^{6, 9} , MD, PhD ;   Michael Barnett   ^{16, 17} , MD, PhD ;   Jeannette Lechner-Scott   ^{1, 2, 3} , MD, PhD

¹ Department of Neurology, John Hunter Hospital, New Lambton Heights, Australia

² School for Medicine and Public Health, University of Newcastle, Callaghan, Australia

³ Hunter Medical Research Institute, New Lambton Heights, Australia

⁴ Institute of Health and Biomedical Innovations, Genomics Research Centre, Queensland University of Technology, Kelvin Grove, Australia

⁵ Department of Neurosciences, Eastern Health Clinical School, Monash University, Box Hill Hospital, Melbourne, Australia

⁶ Department of Neurology, Alfred Health, Melbourne, Australia

⁷ Department of Neurology, Melbourne Multiple Sclerosis Centre, Melbourne Health, Melbourne, Australia

⁸ Centre for Neuromuscular and Neurological Disorders, Perron Institute for Neurological and Translational Science, University of Western Australia, Perth, Australia

⁹ Clinical Outcomes Research (CORe) Unit, Department of Medicine, University of Melbourne, Melbourne, Australia

¹⁰ Institute for Immunology and Infectious Disease, Murdoch University, Perth, Australia

¹¹ Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia

¹² Department of Medicine, University of New South Wales, Sydney, Australia

¹³ Department of Neurology, Liverpool Hospital, Sydney, Australia

¹⁴ Immune Tolerance Laboratory, Ingham Institute, Sydney, Australia

¹⁵ Centre for Clinical Research, University of Queensland, Brisbane, Australia

¹⁶ Brain and Mind Centre, University of Sydney, Sydney, Australia

¹⁷ Sydney Neuroimaging Analysis Centre, Sydney, Australia