The Effects of a Multidomain Lifestyle Intervention on Brain Function and Its Relation With Immunometabolic Markers and Intestinal Health in Older Adults at Risk of Cognitive Decline: Study Design and Baseline Characteristics of the HELI Randomized Controlled Trial

Mark R van Loenen   ^{1, 2 *} , MSc ;   Lianne B Remie   ^{1, 2 *} , MSc ;   Mara PH van Trijp   ³ , PhD ;   Michelle G Jansen   ^{1, 2} , PhD ;   José P Marques   ^{1, 2} , PhD ;   Jurgen AHR Claassen   ^{1, 4} , PhD, MD ;   Ondine van de Rest   ³ , PhD ;   Yannick Vermeiren   ³ , PhD ;   Nynke Smidt   ⁵ , PhD ;   Sietske AM Sikkes   ^{6, 7, 8} , PhD ;   Kay Deckers   ⁹ , PhD ;   Marissa D Zwan   ^{6, 7} , PhD ;   Wiesje M van der Flier   ^{6, 7, 10} , PhD ;   Sebastian Köhler   ⁹ , PhD ;   Wilma T Steegenga   ^{3 †} , PhD ;   Joukje M Oosterman   ^{1, 2 *} , PhD ;   Esther Aarts   ^{1, 2 *} , PhD

¹ Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, The Netherlands

² Donders Centre for Cognitive Neuroimaging, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, The Netherlands

³ Division of Human Nutrition and Health, Wageningen University and Research, Wageningen, The Netherlands

⁴ Department of Geriatrics, Radboud University Medical Center, Radboudumc Alzheimer Center, Nijmegen, The Netherlands

⁵ Department of Epidemiology, University of Groningen, Groningen, The Netherlands

⁶ Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands

⁷ Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands

⁸ Department of Clinical, Neuro and Developmental Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands

⁹ Department of Psychiatry and Neuropsychology, Alzheimer Centrum Limburg, Maastricht University, Maastricht, The Netherlands

¹⁰ Epidemiology & Data Science, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands

*these authors contributed equally

†deceased