This paper is in the following e-collection/theme issue:

RCTs - Protocols/Proposals (non-eHealth) (427) Digital Mental Health Interventions, e-Mental Health and Cyberpsychology (2195) Innovations and Technology for Healthy Eating Education (502) Web-based and Mobile Health Interventions (4116) Digital Biomarkers and Digital Phenotyping (299) Cognitive Training for the Elderly (156)

Published on in Vol 14 (2025)

Preprints (earlier versions) of this paper are available at https://preprints.jmir.org/preprint/69814, first published .
The Effects of a Multidomain Lifestyle Intervention on Brain Function and Its Relation With Immunometabolic Markers and Intestinal Health in Older Adults at Risk of Cognitive Decline: Study Design and Baseline Characteristics of the HELI Randomized Controlled Trial

The Effects of a Multidomain Lifestyle Intervention on Brain Function and Its Relation With Immunometabolic Markers and Intestinal Health in Older Adults at Risk of Cognitive Decline: Study Design and Baseline Characteristics of the HELI Randomized Controlled Trial

The Effects of a Multidomain Lifestyle Intervention on Brain Function and Its Relation With Immunometabolic Markers and Intestinal Health in Older Adults at Risk of Cognitive Decline: Study Design and Baseline Characteristics of the HELI Randomized Controlled Trial

Authors of this article:

Mark R van Loenen1, 2 Author Orcid Image ;   Lianne B Remie1, 2 Author Orcid Image ;   Mara PH van Trijp3 Author Orcid Image ;   Michelle G Jansen1, 2 Author Orcid Image ;   José P Marques1, 2 Author Orcid Image ;   Jurgen AHR Claassen1, 4 Author Orcid Image ;   Ondine van de Rest3 Author Orcid Image ;   Yannick Vermeiren3 Author Orcid Image ;   Nynke Smidt5 Author Orcid Image ;   Sietske AM Sikkes6, 7, 8 Author Orcid Image ;   Kay Deckers9 Author Orcid Image ;   Marissa D Zwan6, 7 Author Orcid Image ;   Wiesje M van der Flier6, 7, 10 Author Orcid Image ;   Sebastian Köhler9 Author Orcid Image ;   Wilma T Steegenga3 Author Orcid Image ;   Joukje M Oosterman1, 2 Author Orcid Image ;   Esther Aarts1, 2 Author Orcid Image
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Journals

  1. Beers S, de Groot L, van Loenen M, Remie L, Bromhaar M, Anesi A, Vrhovsek U, Oosterman J, Aarts E, van Trijp M, Vermeiren Y. Association Between the Dutch Mediterranean‐Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay (MIND‐NL) Diet Adherence and Systemic Tryptophan Metabolites in Older Adults at Risk of Cognitive Decline: An Exploratory Study. Molecular Nutrition & Food Research 2026;70(1) View