Published on in Vol 15 (2026)

Preprints (earlier versions) of this paper are available at https://preprints.jmir.org/preprint/80858, first published .
Real-World Effectiveness and Noninferiority Evaluation and Comparison of Messenger RNA–Based and Protein-Based COVID-19 Vaccines: Protocol for the BEEHIVE Randomized Study With a Hybrid Effectiveness Design

Real-World Effectiveness and Noninferiority Evaluation and Comparison of Messenger RNA–Based and Protein-Based COVID-19 Vaccines: Protocol for the BEEHIVE Randomized Study With a Hybrid Effectiveness Design

Real-World Effectiveness and Noninferiority Evaluation and Comparison of Messenger RNA–Based and Protein-Based COVID-19 Vaccines: Protocol for the BEEHIVE Randomized Study With a Hybrid Effectiveness Design

Sarang K Yoon   1 , DO, MOH ;   German L Ellsworth   2 , MD, MPH, MOH ;   Steph Battan-Wraith   3 , MSPH, PhD ;   Andrew L Phillips   1 , MD, MOH ;   Rebecca V Fink   3 , MPH ;   Joshua Griffin   4 , MHA ;   Elizabeth A K Rowley   3 , DPH, MS ;   Jacob McKell   5 , BS ;   Ashley S Smith   3 , MPH, MLT ;   Riley Campbell   1 , BS ;   Jesse Williams   1 , BS ;   Sarah W Ball   3 , MS, SCD, MPH ;   Hongwei Zhao   2 , SCD ;   Brandy Warren   6 , MPH ;   Matthew D Rousculp   6 , MPH, PhD ;   Matthew S Thiese   2 , MSPH, PhD

1 Division of Occupational and Environmental Health, School of Medicine, University of Utah, Salt Lake City, UT, United States

2 Rocky Mountain Center for Occupational and Environmental Health, University of Utah, Salt Lake City, UT, United States

3 Westat (United States), Rockville, MD, United States

4 The Rocky Mountain Center for Occupational and Environmental Health, School of Medicine, University of Utah, Salt Lake City, UT, United States

5 The Rocky Mountain Center for Occupational and Environmental Health, University of Utah, Salt Lake City, UT, United States

6 Real-World Evidence, Novavax (United States), Gaithersburg, United States

Corresponding Author:

  • Sarang K Yoon, DO, MOH
  • Division of Occupational and Environmental Health
  • School of Medicine
  • University of Utah
  • 50 North Medical Drive
  • Salt Lake City, UT 84132
  • United States
  • Phone: 1 801-213-4500
  • Email: sarang.yoon@hsc.utah.edu